SIBO RESOURCES from Dr. Siebecker          

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Click a button above for the latest SIBO Podcasts, Studies and Events

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15-20% Off Supplements at Fullscript (U.S.)

Fullscript carries over 20,000 professional-grade supplements and body care items. FSA and HSA accounts can be used. Feel free to share the link with friends and family! U.S. only.

Fullscript SIGN UP HERE (free)

15% discount is automatically applied to everything at Fullscript (20% with Autoship at checkout).

Once logged in, see "Community Plans" or "Favorites" for lists of my favorite SIBO supplements.

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Free SIBO Handouts

SIBO Symptomatic Relief Suggestions click here

Problematic Supplements For SIBO click here

Homemade Elemental Diet click here (see my Elemental Diet page for more info)

SIBO - Pregnancy, Lactation, Pediatrics click here

Bone Broth click here (excerpted from my article Traditional Bone Broth in Health and Disease).

SIBO Specific Food Guide click here

SIBO SYMPTOM RELIEF click here

Antibiotic Alternatives to Rifaximin click here

Dr. Siebecker's Quick-Start SIBO Diet click here

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April put here

Free Classes

Latest research updates from Drs. Pimentel and Rezaie - Watch Here

Fructose for SIBO Breath Testing from Dr. Hawrelak - Watch Here

Supplements for Gut Symptom Relief Webinar - Watch Here

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  Dr. Siebecker's Most Recent Quarterly Newsletter
April 2025

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      SIBO CLASSES + EVENTS       

April

Next Steps for Treating Tough SIBO Summit

Join us April 8 - 10, 2025 starting at 8am PDT / 11am Eastern Standard Time

Created by yours truly and co-hosted by Shivan Sarna. This conference is all about alternative treatments for tough cases of SIBO - none of which are antibacterial!  

SIGN UP TO WATCH FREE HERE

Watch 28 masterclasses - free of charge! 

 

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April

Live Expert Panel on
Microbiome Restoration Techniques

April 6, 2025 at 3:00 PM PT

Moderated by Dr. Megan Taylor - experts on this panel include:

• Dr. Jason Hawrelak
• Dr. Mark Davis

• Dr. Andrea McBeth

• Dr. Carly Polland
• Dawn Whitten, BNat(Hons) IBCLC
• Sharon Erdrich, MHSc, PhD Cand
  

Register Here

 

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April

SIBO Awareness Day is April 8th
(April is IBS Awareness Month)

Drs. Pimentel and Rezaie will be live on Instagram - 2pm PT / 5 pm ET April 8th

 

New SIBO Awareness website coming April 8th
www.SIBOawareness.org

  

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May

SIBO and Beyond: Help for Root Causes, Tough Cases, and Stubborn Symptoms Masterclass Summit

 4 day summit - available to watch May 7 - 11, 2025 starting each day at 10am EDT 

My co-host Shivan Sarna and I wanted to go beyond just testing, treatment, and diet for SIBO in this Summit. Our speakers discuss underlying causes of SIBO, stubborn symptoms, tough cases and what to do about it.

Watch 16 Masterclasses taught by amazing, seasoned practitioners - free of charge!  

 REGISTER TO WATCH FREE HERE

 

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          RESEARCH UPDATES & NEWS          

  

> From Dr. Pimentel on X:

Jan 23: "In this massive study by one of the best microbiome research groups in the world, Rifaximin worked in IBS by pushing the microbiome away from the abnormal signature, not damaging the microbiome." PMID: 39243395

Jan 27: "Interesting article just out summarizing the importance of vinculin in IBS, SIBO and scleroderma and others. Anti-vinculin is very important in our work to diagnose IBS-D and M [IBS diarrhea and mixed] as well as future therapies. Very nice." PMID: 39863082

Feb 2: "Great news from DDW 2025. This will be a huge year. Big results on three new therapies for SIBO/IBS, IMO (intestinal methanogen overgrowth), and ISO (intestinal sulfide overproduction). Patients have been waiting a long time for drug therapies."

Mar 14: "Locked and loaded. Good to go from FDA for the next generation multicenter drug trial for IBS-D. We will monitor SIBO and ISO as the driving cofactor. If all paperwork completes on time, first patient in trial in May. We had to self fund this trial. No more waiting!"

Mar 17: "Important new study! Colon cancer appears to be associated with methane producers in the gut like Methanobrevibacter smithii and methane production pathways. We have shown the same archaea causing IMO [Intestinal Methanogen Overgrowth] on breath test. PMID: 39490771

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          SIBO RESOURCES           

Dr. Siebecker's You Tube

I've been posting weekly video clips!
Subscribe / Watch Here

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Supplement Discount 15-20% Off at Fullscript (U.S.)

You are welcome to order through my dispensary for ongoing 15% Off

Fullscript carries 20,000+ high-quality professional supplements, and natural body care, from over 300 brands.

Discount is automatically applied at checkout to everything at Fullscript.
(FSA and HSA accounts can be used.)

To see my favorite SIBO supplements, see "Community Plans" or "Favorites".

 

 SIGN IN / SIGN UP HERE (free)

Feel free to share with friends and family. :)

 

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NEW ELEMENTAL DIET

Elemental Diet Powder

CLICK HERE

--> A recent study using mBIOTA found that 100% of 30 subjects completed the 2-week course (showing good palatability). Normalization rates were: 100% Hydrogen SIBO; 75% Methane + Hydrogen, 58% Methane SIBO/IMO.

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 Elemental Diet Ordering

Some elemental diets are available only through a practitioner.

However, patients can order the following Elemental Diets themselves, via:

1. Functional Medicine Formulations 

 

● Elemental Heal Whey Free (elemental diet)
● Elemental Heal (semi-elemental) - add oil separately   
● Elemental Heal Low Carb (semi-elemental) - add oil separately   
● MCT Oil powder - to add to semi-elemental diets above

Use code ALLISON15 for 15% off

(discount code applies to all supplements they carry)

2. My Fullscript Dispensary (15% Off / 20% with Autoship)

● Integrative Therapeutics: Physicians Elemental Diet and Physicians Elemental Diet Dextrose-Free
● Bioclinic Naturals: ElementAll
● Vita Aid: Elemental Nutrition and Keto-Elemental Nutrition

No Code needed - discount is automatically applied to everything at Fullscript.

 

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SIBO Books

Clinical Understanding of the Human Gut Microbiome by Dr. Mark Pimentel To aid readers, Clinical Understanding of the Human Gut Microbiome integrates a variety of human gut microbiome research so that physicians and clinicians can then make the best decisions in the care of their patients. BUY IT HERE

The Microbiome Connection by Dr. Mark Pimentel Your Guide to IBS, SIBO, and Low-Fermentation Eating  BUY IT HERE

Healing SIBO by Shivan Sarna Half Book, Half Cookbook (+ vegetarian SIBO recipes) "very organized, full of insight, painstakingly researched, highly practical and imbued with warm-hearted fun" - Dr. Sandberg-Lewis BUY IT HERE

SIBO Made Simple by Phoebe Lapine Half Book, Half Cookbook Offers a clear path forward, from someone who's been there. BUY IT HERE

 

Direct-to-Consumer SIBO Tests

Patients (and practitioners without prescription rights) can order Lactulose Breath Tests directly.

 

RUPA Labs
Also available are stool, mold, leaky gut and other functional medicine tests.
 Rupa Labs Test Menu - Order Here   

TRUE HEALTH Labs
U.S. (all states), Canada
Also available are stool, mold, leaky gut and other functional medicine tests.
True Health Labs - order here

 

Learn more about SIBO Testing HERE
Watch my SIBO Testing Masterclass HERE

 

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Dr. Siebecker's SIBO Courses

A veritable wealth of knowledge at your fingertips, plus live Q&A case discussions.  Join me!

PATIENTS - SIBO Recovery Roadmap Course

PRACTITIONERS

• SIBO Pro Course (22 hours - 20 CME)
  
  
• SIBO Pro Mini-Course (3.5 hours) 
  
  
• SIBO Diagnosis and Testing Mini-Course (3 hours)
  

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       SIBO PODCASTS     

Proven Health Alternatives SIBO - Small Intestinal Bacterial Overgrowth with Dr. Allison Siebecker   Check out other recent episodes Here

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Foodniche Changemaker Understanding Food & Digestive Health with Dr. Allison Siebecker   Check out other recent episodes Here

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Rational Wellness DEEPER UNDERSTANDING OF SIBO AND IBS WITH DR. MARK PIMENTEL BEYOND BLOATING: NAVIGATING SIBO WITH DR. MARK PIMENTEL   Check out other recent episodes Here

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Dr. Ruscio Radio How to Tell When ‘SIBO’ Is Actually Candida with Dr. Scott 954 - SIBO, Candida & Parasites - New Treatments  with Dr. Ilana Gurevich   Check out other recent episodes Here

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Check out these other Podcasts for more SIBO related info 

• The Healthy Gut Podcast - Rebecca Coomes
• The SIBO Doctor Podcast - Nirala Jacobi
• The Turd Nerds
• The Rational Wellness Podcast - Dr. Ben Weitz
• Lynda Griparic 
• SIBO Made Simple Podcast
• Healthpath
• REVOLUTION HEALTH - Chris Kressor
• FUNK'TIONAL NUTRITION PODCAST
• The Emoroid Digest Podcast
• The Gut Connection Podcast
• Happy Bones, Happy Life Podcast
  
• The healthy Skin Show
• The Endo Belly Coach 
• Holistic Health Habits Podcast!
• Gut Feeling with Dr Pal - Podcast
• A Little Bit Healthier

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           HOT OFF THE PRESS         
SIBO studies published in the last 3 months

Related

• An evidence-based update on the diagnosis and management of irritable bowel syndrome.  PMID: 39835671

• Amoxicillin Clavulanate  PMID: 30844191
  • Summary: “the efficacy of amoxicillin-clavulanate in treating SIBO approximates 50%.”

• Vinculin: A new target for the diagnosis and treatment of disease. PMID: 39863082

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Overview

• Small intestinal bacterial overgrowth: from malabsorption to misinterpretation.  PMID: 39804239

• [Small intestine bacterial overgrowth: Myths and realities].  PMID: 39799751

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Causes/ Risk Factors

Cystic Fibrosis

• Low Plasma Choline, High Trimethylamine Oxide, and Altered Phosphatidylcholine Subspecies Are Prevalent in Cystic Fibrosis Patients with Pancreatic Insufficiency.  PMID: 40077735

Diseases

• Traumatic Brain Injury and Gut Microbiome: The Role of the Gut-Brain Axis in Neurodegenerative Processes.  PMID: 40087204

  • Summary: “Damage to the CNS associated with TBI leads to GI dysmotility, which promotes small intestinal bacterial overgrowth (SIBO).”
    

Endometriosis

• High prevalence of small intestinal bacterial overgrowth and intestinal methanogen overgrowth in endometriosis patients: A case-control study.  PMID: 39959963

  • Summary: high prevalence of SIBO in Endometriosis, especially methane with increased prevalence of constipation, dizziness and acid reflux, although some have hydrogen and diarrhea.

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Pathophysiology

• Comparative analysis of amino acid auxotrophies and peptidase profiles in non-dysbiotic and dysbiotic small intestinal microbiomes.  PMID: 40103612

  • Summary: “In SIBO, the small intestinal microbiome shifts towards a metabolic state resembling that of the large intestine, particularly in its increased abundance of extracellular peptidase genes.”

• European Consensus on Malabsorption-UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN: Part 2: Screening, Special Populations, Nutritional Goals, Supportive Care, Primary Care Perspective.  PMID: 40088199

• [Clinical challenge 2. Digestive. Intestinal dysmotility beyond small intestine bacterial overgrowth. The challenge of meeting nutritional requirements].  PMID: 40008640

• Influence of menstrual cycle and oral contraception on taxonomic composition and gas production in the gut microbiome  PMID: 40153295

  • Summary: This study explored “the relationship of OC [oral contraception] use and the microbiome to gas production, which can cause symptoms“.

    “We found a strong correlation between H2 [hydrogen] and CH4 [methane] concentrations and an interaction between OC [oral contraception] use and the menstrual cycle on H2 and CH4 production. We also identified several taxa associated with both high levels of H2 and CH4 production and OC use.” Microbial richness was greater on day 21 vs day 2 of cycle.

Hydrogen Sulfide

• Development of a Transcriptional Biosensor for Hydrogen Sulfide that Functions under Aerobic and Anaerobic Conditions  PMID: 40027654

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Associated Conditions

NEW Bile Acid Dysmetabolism

• Bile acid dysmetabolism in Bangladeshi infants is associated with poor linear growth, enteric inflammation, and small intestine bacterial overgrowth.  PMID: 39973996 

Cystic Fibrosis

• Low Plasma Choline, High Trimethylamine Oxide, and Altered Phosphatidylcholine Subspecies Are Prevalent in Cystic Fibrosis Patients with Pancreatic Insufficiency.  PMID: 40077735

Endometriosis

• High prevalence of small intestinal bacterial overgrowth and intestinal methanogen overgrowth in endometriosis patients: A case-control study.  PMID: 39959963

  • Summary: high prevalence of SIBO in Endometriosis, especially methane with increased prevalence of constipation, dizziness and acid reflux, although some have hydrogen and diarrhea.

GERD

• Correlation Between Gastroesophageal Reflux Disease and Small Intestinal Bacterial Overgrowth: Analysis of Intestinal Microbiome and Metabolic Characteristics. PMID: 39780983

  • Summary: “GERD is strongly linked to SIBO, especially in patients with a positive CH₄ [methane] breath test. The gut microbiota in GERD and SIBO patients differs from healthy individuals, with bacteroides uniformis as a key marker. Metabolic changes are mainly related to ABC transporter metabolites.”

Halitosis

• Extraoral halitosis in functional dyspepsia and its association with small intestinal bacterial overgrowth. PMID: 39903942

IBD (Inflammatory Bowel Disease)

• Prevalence and predictors of small intestinal bacterial overgrowth in inflammatory bowel disease: a meta-analysis  PMID: 39906350 
  • Summary: “Nearly one-third of IBD patients present with SIBO, and the odds of SIBO in IBD was increased by 5.25-fold compared with healthy controls. Lower BMI, bloating, flatulence, history of abdominal surgery, and structuring… were predictors of SIBO in IBD patients.”
    

IBS (Irritable Bowel Syndrome)

• Impact of Positive Glucose, Lactose, and Fructose Hydrogen Breath Tests on Symptoms and Quality of Life in Irritable Bowel Syndrome.  PMID: 39854015

Liver Disease

• Small Intestinal Bacterial Overgrowth Is a Predictor of Overt Hepatic Encephalopathy in Patients with Liver Cirrhosis.  PMID: 40094949 

• Small intestinal bacterial overgrowth in chronic liver disease: an updated systematic review and meta-analysis of case-control studies.  PMID: 39844931

Traumatic Brain Injury

• Traumatic Brain Injury and Gut Microbiome: The Role of the Gut-Brain Axis in Neurodegenerative Processes.  PMID: 40087204

  • Summary: “Damage to the CNS associated with TBI leads to GI dysmotility, which promotes small intestinal bacterial overgrowth (SIBO).”

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 Testing

• Usefulness of a Digital Tool to Improve Methodology and Reporting of Breath Tests for Small Intestinal Bacterial Overgrowth.  PMID: 40013842

  • Summary: “The use of a web-based digital tool specifically developed to assist the entire BT process appears to improve accuracy and quality of reports.”

• Development of a Transcriptional Biosensor for Hydrogen Sulfide that Functions under Aerobic and Anaerobic Conditions  PMID: 40027654

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 Treatment

• Drugs for irritable bowel syndrome.  PMID: 39912839
• Comparison chart: Safety of drugs for IBS in pregnancy and lactation.  PMID: 39912840

• Comparison chart: Some drugs for irritable bowel syndrome with diarrhea (IBS-D).  PMID: 39912844

Antibiotics

• DIAGNOSIS AND TREATMENT OF SMALL INTESTINAL BACTERIAL OVERGROWTH: AN OFFICIAL POSITION PAPER FROM THE BRAZILIAN FEDERATION OF  GASTROENTEROLOGY  PMID: 39968993
  • Summary:“Treatment with rifaximin is effective in most cases of SIBO, while systemic antibiotics likemetronidazole and ciprofloxacin are alternatives. ...Long-term follow-up is essential due to therecurrence rate, which is common in SIBO patients.”
• Comparison of Rifaximin Monotherapy and Rifaximin Combined with Probiotics in Patients with Irritable Bowel Syndrome: A Randomized Controlled Trial.  PMID: 40077633

  • Summary: “Rifaximin combined with probiotics was superior to rifaximin monotherapy in patients with IBS. … The multi-strain probiotic contained six strains: Lactobacillus gasseri, Lactobacillus rhamnosus, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium bifidum, and Bifidobacterium lactis at a dose of 1 × 10¹⁰ CFUs”, taken as 1/day x 28 days. Rifaximin was taken x 14 days.

Probiotics

• A Comprehensive Review of the Usefulness of Prebiotics, Probiotics, and Postbiotics in the Diagnosis and Treatment of Small Intestine Bacterial Overgrowth.  PMID: 39858825

• Comparison of Rifaximin Monotherapy and Rifaximin Combined with Probiotics in Patients with Irritable Bowel Syndrome: A Randomized Controlled Trial.  PMID: 40077633

  • Summary: “Rifaximin combined with probiotics was superior to rifaximin monotherapy in patients with IBS. … The multi-strain probiotic contained six strains: Lactobacillus gasseri, Lactobacillus rhamnosus, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium bifidum, and Bifidobacterium lactis at a dose of 1 × 10¹⁰ CFUs”, taken as 1/day x 28 days. Rifaximin was taken x 14 days.

Diet: FODMAP Diet

• Low-FODMAP Diet for Irritable Bowel Syndrome: Insights from Microbiome.  PMID: 39940404

• FODMAP Profile of Wholegrain Pasta.  PMID: 40002111

• The effects of low FODMAP diet on gut microbiota regulation: A systematic review and meta-analysis. PMID: 40035292 

• The Efficacy of the Low-FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) Diet in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.  PMID: 39917138

• Elimination Diets.  PMID: 38261686 Free Books & Documents.

• Relationship Between FODMAP Diet and Irritable Bowel Syndrome: A Mendelian Randomization Study. PMID: 39968214 Free PMC article.

• Successful Strategy in Creating Low-FODMAP Wholegrain Bread-Simple and Global.  PMID: 39856969

• The low FODMAP diet in adolescents functional abdominal in a non-guided setting: a prospective multicenter cohort study.  PMID: 39934502

• IBS and IBD-One Letter, Much Pain, Few Treatments.  PMID: 39953184 No abstract available.

• Biotechnological Tools for the Production of Low-FODMAP Wholegrain Wheat and Rye Cookies and Crackers.  PMID: 40002026 Free PMC article.

• A Bifunctional "Two-in-One" Array for Simultaneous Diagnosis of Irritable Bowel Syndrome and Identification of Low-FODMAP Diets.  PMID: 39785268

• Low FODMAP diet in children with functional abdominal pain disorders. Is it always worth trying?: Low FODMAP diet in children with functional abdominal pain disorders.  PMID: 39988545

• Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Clinical Trials.  PMID: 39110917

• Case Series: Management of Exercise-Associated Gastrointestinal Symptoms in Endurance Athletes Using a High-Carbohydrate Low-FODMAP Therapeutic Intervention.  PMID: 40049175

• Irritable bowel syndrome, the gut microbiome, and diet.  PMID: 39968682

• DIAGNOSIS AND TREATMENT OF SMALL INTESTINAL BACTERIAL OVERGROWTH: AN OFFICIAL POSITION PAPER FROM THE BRAZILIAN FEDERATION OF GASTROENTEROLOGY.  PMID: 39968993

• Nutrition Interventions in the Treatment of Endometriosis: A Scoping Review.  PMID: 39696836

• Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases.  PMID: 39959156 Free PMC article. Review.

• Effects of Probiotics and Diet Management in Patients With Irritable Bowel Syndrome: A Systematic Review and Network Meta-analysis.  PMID: 39862384

• Is there a sex difference in response to FODMAP diet group education for IBS? A clinical practice service evaluation.  PMID: 40094779

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Check out all the SIBO research on SIBOinfo.com:
Studies and Associated Diseases  

 

NOT TO BE MISSED! 

Did you miss an email or event in the past 3 months? Here's what happened:

• SIBO Masterclass: Useful Updates and Help for Tough Cases- Click Here
  
• 2 Masterclass Bundle: How to Fix Your Microbiome and Probiotics in the Management of IBS, SIBO / IMO / ISO with Dr. Jason Hawrelak - Click here
• SIBO Pro Mini-Course with Dr. Siebecker - More Info Here